net_left Phương Thức Thanh Toán
Phương Thức Thanh Toán

Acadia Shares Fall on Negative NUPLAZID AdCom Vote, Prompting JP Morgan Downgrade

By Vlad Schepkov Shares of Acadia Pharmaceuticals (NASDAQ:ACAD) are recording heavy losses Tuesday morning – down as much as 29% in pre-market trading – following late Friday’s...
Acadia Shares Fall on Negative NUPLAZID AdCom Vote, Prompting JP Morgan Downgrade © Reuters. Acadia (ACAD) Shares Plunge on Negative NUPLAZID AdCom Vote, Prompting JP Morgan Downgrade

By Vlad Schepkov

Shares of Acadia Pharmaceuticals (NASDAQ:ACAD) are recording heavy losses Tuesday morning – down as much as 29% in pre-market trading – following late Friday’s announcement of a negative FDA Advisory Committee (AdCom) vote over the efficacy of the company’s pimavanserin (marketed as NUPLAZID) drug for Alzheimer’s disease psychosis (ADP) indication.

The vote, called by JP Morgan’s Cory Kasimov “Nuplazid's potentially last high-risk / high-reward shot”, and generally considered Acadia’s key binary catalyst event brought an unsettling conclusion for the company - the panel decided 9 against 3 that evidence presented does not clearly demonstrate the drug’s efficacy.

Despite the stock’s vicious reaction, Kasimov believes the outcome “isn’t overly surprising”, given “the FDA's exclusive focus on efficacy and not the overall benefit /risk.” The analyst admits that Nuplazid’s chances to be approved for ADP are very slim, as the company has publicly stated its unwillingness to commit to another trial.

JP Morgan thus downgrades the stock to “Neutral” from “Outperform”, noting that “it will be difficult for ACAD to outperform our broader coverage universe.”

Gregory Renza of RBC Capital Markets maintains a more positive tone: admitting that “with the negative AdComm, we see increased likelihood of FDA rejection of the application in August” (pimavanserin in ADP has a PDUFA of August 22nd, 2022), he also believes “the stock implication is limited at current levels given a PDP floor.”

RBC Capital Markets cuts the price target to $26 from $32 but reiterates “Outperform” rating: “the set- up for ACAD still remains serviceable revenue generation from Nuplazid, optionality left for pimavanserin in Schizo-NS and a long-shot ADP, and the emergence of second drug, NDA-set trofinetide, as an added leg of growth.”

Shares of ACAD plummeted briefly to $11.86 – a lot not seen since mid-2013, before recouping some losses.

Hot Auto Trade Bot Phương Thức Thanh Toán
BROKERS ĐƯỢC CẤP PHÉP
net_home_top Ai VIF
01-07-2022 03:27:23 (UTC+7)

EUR/USD

1.0484

+0.0045 (+0.43%)

Summary

↑ Buy

Moving Avg:

Buy (11)

Sell (1)

Indicators:

Buy (6)

Sell (2)

EUR/USD

1.0484

+0.0045 (+0.43%)

Summary

↑ Buy

Moving Avg:

Buy (11)

Sell (1)

Indicators:

Buy (6)

Sell (2)

GBP/USD

1.2173

+0.0048 (+0.40%)

Summary

Neutral

Moving Avg:

Buy (6)

Sell (6)

Indicators:

Buy (5)

Sell (1)

USD/JPY

135.71

-0.87 (-0.63%)

Summary

Neutral

Moving Avg:

Buy (11)

Sell (1)

Indicators:

Buy (1)

Sell (5)

AUD/USD

0.6904

+0.0022 (+0.33%)

Summary

↑ Buy

Moving Avg:

Buy (11)

Sell (1)

Indicators:

Buy (7)

Sell (1)

USD/CAD

1.2873

-0.0019 (-0.14%)

Summary

Sell

Moving Avg:

Buy (2)

Sell (10)

Indicators:

Buy (3)

Sell (3)

EUR/JPY

142.29

-0.29 (-0.21%)

Summary

Buy

Moving Avg:

Buy (11)

Sell (1)

Indicators:

Buy (4)

Sell (4)

EUR/CHF

1.0008

+0.0037 (+0.37%)

Summary

Neutral

Moving Avg:

Buy (10)

Sell (2)

Indicators:

Buy (2)

Sell (4)

Gold Futures

1,808.15

-9.35 (-0.51%)

Summary

↑ Buy

Moving Avg:

Buy (10)

Sell (2)

Indicators:

Buy (7)

Sell (1)

Silver Futures

20.240

-0.498 (-2.40%)

Summary

Neutral

Moving Avg:

Buy (4)

Sell (8)

Indicators:

Buy (7)

Sell (1)

Copper Futures

3.6815

-0.0990 (-2.62%)

Summary

↑ Sell

Moving Avg:

Buy (0)

Sell (12)

Indicators:

Buy (0)

Sell (9)

Crude Oil WTI Futures

105.84

-3.94 (-3.59%)

Summary

Buy

Moving Avg:

Buy (10)

Sell (2)

Indicators:

Buy (3)

Sell (3)

Brent Oil Futures

109.14

-3.31 (-2.94%)

Summary

↑ Sell

Moving Avg:

Buy (0)

Sell (12)

Indicators:

Buy (0)

Sell (8)

Natural Gas Futures

5.526

-0.972 (-14.96%)

Summary

↑ Sell

Moving Avg:

Buy (0)

Sell (12)

Indicators:

Buy (0)

Sell (8)

US Coffee C Futures

230.28

+2.03 (+0.89%)

Summary

Neutral

Moving Avg:

Buy (5)

Sell (7)

Indicators:

Buy (3)

Sell (3)

Euro Stoxx 50

3,454.86

-59.46 (-1.69%)

Summary

↑ Buy

Moving Avg:

Buy (12)

Sell (0)

Indicators:

Buy (6)

Sell (3)

S&P 500

3,785.38

-33.45 (-0.88%)

Summary

↑ Buy

Moving Avg:

Buy (8)

Sell (4)

Indicators:

Buy (6)

Sell (2)

DAX

12,783.77

-219.58 (-1.69%)

Summary

Neutral

Moving Avg:

Buy (7)

Sell (5)

Indicators:

Buy (2)

Sell (3)

FTSE 100

7,169.28

-143.04 (-1.96%)

Summary

Sell

Moving Avg:

Buy (6)

Sell (6)

Indicators:

Buy (1)

Sell (6)

Hang Seng

21,859.79

-137.10 (-0.62%)

Summary

Sell

Moving Avg:

Buy (1)

Sell (11)

Indicators:

Buy (3)

Sell (3)

US Small Cap 2000

1,699.68

-19.69 (-1.15%)

Summary

Neutral

Moving Avg:

Buy (1)

Sell (11)

Indicators:

Buy (5)

Sell (4)

IBEX 35

8,098.70

-89.30 (-1.09%)

Summary

Sell

Moving Avg:

Buy (6)

Sell (6)

Indicators:

Buy (1)

Sell (7)

BASF SE NA O.N.

41.525

-0.055 (-0.13%)

Summary

↑ Buy

Moving Avg:

Buy (8)

Sell (4)

Indicators:

Buy (6)

Sell (1)

Bayer AG NA

56.72

-0.90 (-1.56%)

Summary

Neutral

Moving Avg:

Buy (6)

Sell (6)

Indicators:

Buy (2)

Sell (2)

Allianz SE VNA O.N.

182.12

-1.60 (-0.87%)

Summary

Sell

Moving Avg:

Buy (6)

Sell (6)

Indicators:

Buy (1)

Sell (6)

Adidas AG

168.76

-1.26 (-0.74%)

Summary

Buy

Moving Avg:

Buy (8)

Sell (4)

Indicators:

Buy (5)

Sell (3)

Deutsche Lufthansa AG

5.564

-0.249 (-4.28%)

Summary

↑ Buy

Moving Avg:

Buy (12)

Sell (0)

Indicators:

Buy (10)

Sell (0)

Siemens AG Class N

97.09

-4.31 (-4.25%)

Summary

↑ Sell

Moving Avg:

Buy (4)

Sell (8)

Indicators:

Buy (2)

Sell (6)

Deutsche Bank AG

8.318

-0.253 (-2.95%)

Summary

Neutral

Moving Avg:

Buy (7)

Sell (5)

Indicators:

Buy (3)

Sell (4)

 EUR/USD1.0484↑ Buy
 GBP/USD1.2173Neutral
 USD/JPY135.71Neutral
 AUD/USD0.6904↑ Buy
 USD/CAD1.2873Sell
 EUR/JPY142.29Buy
 EUR/CHF1.0008Neutral
 Gold1,808.15↑ Buy
 Silver20.240Neutral
 Copper3.6815↑ Sell
 Crude Oil WTI105.84Buy
 Brent Oil109.14↑ Sell
 Natural Gas5.526↑ Sell
 US Coffee C230.28Neutral
 Euro Stoxx 503,454.86↑ Buy
 S&P 5003,785.38↑ Buy
 DAX12,783.77Neutral
 FTSE 1007,169.28Sell
 Hang Seng21,859.79Sell
 Small Cap 20001,699.68Neutral
 IBEX 358,098.70Sell
 BASF41.525↑ Buy
 Bayer56.72Neutral
 Allianz182.12Sell
 Adidas168.76Buy
 Lufthansa5.564↑ Buy
 Siemens AG97.09↑ Sell
 Deutsche Bank AG8.318Neutral
Mua/Bán 1 chỉ SJC
# So hôm qua # Chênh TG
SJC Eximbank6,810/ 6,870
(0/ 0) # 1,764
SJC HCM6,830/ 6,890
(0/ 0) # 1,783
SJC Hanoi6,830/ 6,892
(0/ 0) # 1,785
SJC Danang6,830/ 6,892
(0/ 0) # 1,785
SJC Nhatrang6,830/ 6,892
(0/ 0) # 1,785
SJC Cantho6,830/ 6,892
(0/ 0) # 1,785
Cập nhật 01-07-2022 03:27:26
Xem lịch sử giá vàng SJC: nhấn đây!
ↀ Giá vàng thế giới
$1,806.57-12.49-0.69%
Live 24 hour Gold Chart
ʘ Giá bán lẻ xăng dầu
Sản phẩmVùng 1Vùng 2
RON 95-V33.47034.130
RON 95-III32.87033.520
E5 RON 92-II31.30031.920
DO 0.05S30.01030.610
DO 0,001S-V30.81031.420
Dầu hỏa 2-K28.78029.350
ↂ Giá dầu thô thế giới
WTI$105.91+1.651.55%
Brent$109.22+1.141.05%
$ Tỷ giá Vietcombank
Ngoại tệMua vàoBán ra
USD23.105,0023.415,00
EUR23.704,3925.032,07
GBP27.520,9428.694,87
JPY165,73175,46
KRW15,5118,90
Cập nhật lúc 18:51:16 30/06/2022
Xem bảng tỷ giá hối đoái
Phương Thức Thanh Toán